Global political dynamics in the post-pandemic era have experienced significant changes that affect international relations, the economy and security. The COVID-19 pandemic is not only a health crisis, but has also triggered a transformation in global power patterns. Previously dominant countries are now facing new challenges, while other countries are taking the opportunity to strengthen their positions. First, the shift in power towards Asia is becoming clearer. Countries like China and India are showing rapid economic growth, making them influential on the global stage. China, in particular, has become increasingly active in health diplomacy, distributing vaccines to various countries and increasing its influence in Asia and Africa. The Belt and Road Initiative (BRI) is also increasingly important in strengthening its infrastructure network. Meanwhile, the US, previously at the pinnacle of global power, is now facing an internal dilemma. Issues such as political polarization, an unstable economy, and challenges from Chinese influence are forcing the US to readjust its foreign strategy. Joe Biden’s foreign policy emphasizes multilaterality and cooperation with allies, however, challenges from Russia and China still require serious attention. In Europe, Brexit and its impact on the European Union adds complexity to political dynamics. Many member states face internal tensions around issues of immigration and national identity. The EU’s resilience in facing crises, such as collective purchasing of vaccines, shows the importance of solidarity in facing global challenges. Global security is also experiencing shifts with increasing cyber threats and terrorism. Countries are strengthening digital infrastructure to protect themselves from cyber attacks, and international cooperation in this regard is vital. The G7 and G20 summits have become important forums for discussing these issues, as well as climate issues. In addition, climate change is an urgent issue that encourages countries to collaborate. The COP26 Climate Change Conference in Glasgow is an important moment for countries to affirm their commitment to reducing carbon emissions. Countries that ignore this issue may face sanctions from the international community. Social issues are also increasingly dominating global politics. Pro-democracy and human rights movements, especially in authoritarian countries, demand attention from world leaders. Digital activism and social media play an important role in spreading the word, making countries more responsible. Finally, technological developments also shape global political dynamics. Innovations in communications, transportation, and health have changed the way countries interact. Telemedicine, for example, makes healthcare access more equitable, but also raises privacy challenges. With all these dynamics, the post-pandemic era requires countries to adapt and innovate in their policies. Deepening interconnectedness influences not only domestic policy, but also global strategy. Adaptation to these changes is the key to facing future challenges.